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The study protocol was accredited by the University of Michigan and Harper Healthcare facility human-research committees. The individuals had been interviewed to the day in their Original evaluations during the cardiac-surgical procedure outpatient clinic. The sufferers who consented ended up randomly assigned inside of a double-blind trend to begin oral therapy on the exact same day. Sufferers were enrolled a indicate (±SD) of 13±7 times before surgical procedures. Amiodarone (Cordarone, Wyeth–Ayerst Laboratories, Philadelphia) was prescribed in a dosage of 1 tablet (200 mg) thrice every day for 7 times, then a single pill every day while the individual was hospitalized.
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Amiodarone was perfectly tolerated and did not enhance the risk of intraoperative or postoperative problems. Amiodarone therapy was not associated with proarrhythmia or serious adverse reactions, even amid patients with severe coronary and valvular heart disease. Among the individuals who did have atrial fibrillation, amiodarone diminished the ventricular rate much more drastically than did placebo.
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